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Showing 1 results for Schwartz Cirteria
Shohre Jalaei, Soghrat Faghihzadeh, Farzad Eskandari, Touba Ghazanfari, Volume 2, Issue 1 (8-2008)
Abstract
Part of the recent literature on the evaluation of surrogate endpoints is started by a definition of validity in terms of both trial-level and individual-level association between a potential surrogate and a true endpoint. In another part, we review the main considerable statistical methods being proposed for the evaluation of a biomarker as surrogate endpoints, which have developed and consider how the validation process might be arranged within the regulatory and practical constraints evaluation. In the present work, we propose a new. Bayesian approach to evaluate individual level surrogacy. Deferent variations to prior distributions were implemented for responses with binomial distribution. Then these methods are compared in a simulation study. Finally, we apply and compare the previous and new methodology using a clinical study.
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