In many medical studies, in order to describe the course of illness and treatment effects, longitudinal studies are used. In longitudinal studies, responses are measured frequently over time, but sometimes these responses are discrete and with two-state. Recently Binary quantile regression methods to analyze this kind of data have been taken into consideration. In this paper, quantile regression model with Lasso and adaptive Lasso penalty for longitudinal data with dichotomous responses is provided. Since in both methods posteriori distributions of the parameters are not in explicit form, thus the full conditional posteriori distributions of parameters are calculated and the Gibbs sampling algorithm is used to deduction. To compare the performance of the proposed methods with the conventional methods, a simulation study was conducted and at the end, applications to a real data set are illustrated.

This paper considers the problem of simultaneous variable selection and estimation in a semiparametric mixed-effects model for longitudinal data with normal errors. We approximate the nonparametric function by regression spline and simultaneously estimate and select the variables under the optimization of the penalized objective function. Under some regularity conditions, the asymptotic behaviour of the resulting estimators is established in a high-dimensional framework where the number of parametric covariates increases as the sample size increases. For practical implementation, we use an EM algorithm to selects the significant variables and estimates the nonzero coefficient functions. Simulation studies are carried out to assess the performance of our proposed method, and a real data set is analyzed to illustrate the proposed procedure.