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Mehdi Akbarzadeh, Hamid Alavimajd, Yadollah Mehrabi, Maryam Daneshpoor, Anvar Mohammadi, Volume 3, Issue 2 (3-2010)
Abstract
One of the important problems that bring up in genetic fields is determining of loci of special gene in order to gene mapping and generating more effective drugs in medicine. Genetic linkage analysis is one important stage in this way. Haseman-Elston method is a quantitative statistical method that is used by biostatisticians and geneticists for genetic linkage analysis. The original Haseman-Elston method is presented in the year 1972 and ever after many investigators recommended some suggestions to make better it. In this article, we introduce the Haseman-Elston regression method and its extensions through 1972 to 2009. and finally we show performance of these methods in a practical example.
Mohammad Gholami Fesharaki, Anoshirvan Kazemnejad, Farid Zayeri, Volume 6, Issue 1 (8-2012)
Abstract
Skew Normal distribution is important in analyzing non-normal data. The probability density function of skew Normal distribution contains integral function which tends researchers to some problems. Because of this problem, in this paper a simpler Bayesian approach using conditioning method is proposed to estimate the parameters of skew Normal distribution. Then the accuracy of this metrology is compared with ordinary Bayesian method in a simulation study.
Mitra Rahimzadeh, Ahmad Reza Baghestani, Behrooz Kavehei, Volume 7, Issue 1 (9-2013)
Abstract
On Hypergeometric Generalized Negative Binomial Distribution in Promotion Time Cure Model In analysis of survival data if exposes a high percentage of censoring due to termination of the study, whereas the study has lasted long enough, it is preferred to utilize cure models. These models, which are based on the latent variable distribution, has obtained much attention in the last decade. In this paper the Hypergeometric Generalized Negative Binomial distribution of the latent variable is used to model the long time survival data. The new model parameters are estimated in Bayesian approach. This model is applied for a Primary Biliary Cirrhosis clinical trial data and a simulated data set. With respect to DIC, Hypergeometric Generalized Negative Binomial model is a suitable fit to the data.
Mohammad Gholami Fesharaki, Anoshirvan Kazemnejad, Farid Zayeri, Volume 7, Issue 2 (3-2014)
Abstract
In two level modeling, random effect and error's normality assumption is one of the basic assumptions. Violating this assumption leads to incorrect inference about coefficients of the model. In this paper, to resolve this problem, we use skew normal distribution instead of normal distribution for random and error components. Also, we show that ignoring positive (negative) skewness in the model causes overestimating (underestimating) in intercept estimation and underestimating (overestimating) in slope estimation by a simulation study. Finally, we use this model to study relationship between shift work and blood cholesterol.
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