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Non-invasive NIPT test has been used in trisomy 21 screening. However, there is a possibility of misdiagnosis in the methods used to diagnose Down syndrome. Therefore, it is essential to provide a process that can be used alongside these methods to improve efficiency. The main goal of this article is to design a model based on machine learning algorithms for the early diagnosis of Down syndrome. Machine learning algorithms such as support vector machine, simple Bayes, decision tree, random forest, and nearest neighbor, which are frequently used to improve the diagnosis of disorders, have been implemented on the mentioned dataset. The performance of each model on the Down syndrome dataset was investigated, and the most suitable model for this purpose was introduced.