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                                  Evaluation of Surrogate Endpoints by Bayesian Method
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								    Shohre Jalaei     ,   Soghrat Faghihzadeh *     ,  Farzad Eskandari     ,  Touba Ghazanfari      | 
								
								
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                                  Abstract:       (6955 Views)  | 
								
								
								  Part of the recent literature on the evaluation of surrogate endpoints is started by a definition of validity in terms of both trial-level and individual-level association between a potential surrogate and a true endpoint. In another part, we review the main considerable statistical methods being proposed for the evaluation of a biomarker as surrogate endpoints, which have developed and consider how the validation process might be arranged within the regulatory and practical constraints evaluation. In the present work, we propose a new. Bayesian approach to evaluate individual level surrogacy. Deferent variations to prior distributions were implemented for responses with binomial distribution. Then these methods are compared in a simulation study. Finally, we apply and compare the previous and new methodology using a clinical study. 
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								  | Keywords:  Surrogate Endpoints, Evaluation, Individual-level, Prentie’s Criteria, Bayes Factor, Schwartz Cirteria | 
								
								
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                                  Type of Study:  Applied |
                                  Subject: 
                                  Biostatistics    Received: 2018/11/16 | Accepted: 2018/11/16 | Published: 2018/11/16
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