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In the present era, classification of data is one of the most important issues in various sciences in order to
detect and predict events. In statistics, the traditional view of these classifications will be based on classic
methods and statistical models such as logistic regression. In the present era, known as the era of explosion
of information, in most cases, we are faced with data that cannot find the exact distribution. Therefore, the
use of data mining and machine learning methods that do not require predetermined models can be useful.
In many countries, the exact identification of the type of groundwater resources is one of the important
issues in the field of water science. In this paper, the results of the classification of a data set for groundwater resources were compared using regression, neural network, and support vector machine.
The results of these classifications showed that machine learning methods were effective in determining the exact type of springs.

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Today, applying statistics in other sciences, including medical sciences, has become very common. Researchers consider optimal design as a tool to increase the efficiency of experiments.
Pharmacokinetics is particularly important in the medical sciences as a branch of pharmacology that studies the performance of drugs in living organisms.
This study aims to introduce optimal designs for models in pharmacokinetic studies. The models used in this paper are known as nonlinear models in the statistical literature. These models depend on specific parameters based on pharmacological factors and time as predictor variables.
Optimal designs are obtained based on functions of the Fisher information matrix. These functions are known as optimal criteria. In this paper, we consider two criteria, A- and E-optimality. Based on these two criteria, locally optimal designs are obtained for the considered models.